Poxviridae

Saturday, January 31, 2009

Genome Structure

The genome is not segmented and it contains a single molecule of linear double-stranded DNA. The complete genome is about 130000-375000 nucleotides long. The genome contains guanine-cytosine and has terminally redundant sequences. The terminally redundant sequences have reiterated inverted terminal sequences which are tandemly repeated. Its genome sequence is repeated at both ends and dsDNA is covalently bonded. dsDNA is cross-linked at both ends.

The viral genome encodes both structural proteins and non-structural proteins. Lipids are present in the envelope. It contributes 4% of the bacterial weight. The composition of viral lipids and host cell membranes are similar.

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